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鶹ýƵվ researchers to explore the elements of effective mental heath treatments

11 May 2023

Five 鶹ýƵվ-led research teams will receive a share of £47m from the Wellcome Trust to investigate what makes the most effective interventions for anxiety, depression and psychosis work so well.

Photo of walkers in Banff National Park Canada by Jaime Reimer from Pexels: https://www.pexels.com/photo/two-person-walking-on-unpaved-road-2679814/

The award seeks to tackle a research gap that has been identified around treatments for these conditions, which affect millions of people around the world. The aim of the research is to inform the improvement of existing treatments and the development of new ones.

The teams, led by researchers from the Division of Psychiatry and the Institute of Cognitive Neuroscience, who are also affiliated to 鶹ýƵվ’s Institute of Mental Health, will investigate the active ingredients in each effective therapy to find out how and why they work.

Each team will receive up to £5m to investigate these interventions and will work in collaboration with potential recipients for these treatments.

The awards to 鶹ýƵվ teams are as follows:

The mechanisms underlying the antidepressant effects of physical activity
Professor Jonathan Roiser, Institute of Cognitive Neuroscience
Surprises as a mechanism of improvement in the psychological therapy of anxiety and depression in young people
Professor Argyris Stringaris,Division of Psychiatry
Immune mechanisms of antipsychotic treatment response
Dr Katharina Schmack, The Francis Crick Institute, UK and Division of Psychiatry, 鶹ýƵվ
Learning mechanisms of pharmacological treatments for depression (RELMED)
Professor Quentin Huys, Division of Psychiatry
EM-BODY: Interoceptive mechanisms of emotion in mental health treatment
Professor Sarah Garfinkel, Institute of Cognitive Neuroscience
This project is co-led with Dr Camilla Nord,University of Cambridge

You can read about the details of each project on the .

Professor Anthony David, director of the Institute of Mental Health, said:

“We are delighted that 鶹ýƵվ researchers have done so well in the recent Wellcome awards for work that will lead to new interventions for anxiety, depression and psychosis.

“The Institute of Mental Health was set up almost five years ago to form a network for all those researchers at 鶹ýƵվ interested in mental health, regardless of department or discipline, to put us in a unique position to help turn the tide on this global crisis.

“The projects exemplify the IoMH’s interdisciplinary ethos and our raison d’etre of bringing researchers together.”

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