Bioinformatics
In cell biology, new approaches to imaging - including high-throughput imaging, super-resolution imaging and high-resolution datasets from 3D models or tissues - generate huge image data sets. In the past, such images could only be analysed visually, leading to a biased and incomplete set of possible interpretations.Ìý
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The Bioinformatics Image Core (BIONIC) Ìýhas trained bioinformaticians which link biology with mathematics, image processing, computer science and statistics to develop computational tools for image analysis. We use PerkinElmer Opera and Phenix high-content screening microscopes, ImageJ analysis software and the statistical program R with Bioconductor packages such as CellHTS2, Ìýin monolayer and 3D tissue culture.Ìý
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Key methodologies include:
- Applied image segmentation
- Thresholding
- Morphological operations
- Filtering
- Feature extractions
- High-throughput statistical analysis
- Algorithm development
Selected publications
Wilson GA et al (2023).Ìý. 
Molecular Cell 83(22):4078-4092.e6 doi: 10.1016/j.molcel.2023.10.017
Papandreou A et al (2023). .Ìý
SLAS Discovery doi: 10.1016/j.slasd.2022.12.002
Ketteler R, Kriston-Vizi J (2022).Ìý: Volume 1-6, Second Edition: 472-483 doi: 10.1016/B978-0-12-821618-7.00032-8
Kriston-Vizi J et al (2022).Ìý 
Journal of Immunology Research 2022:1-9 
doi: 10.1155/2022/9493019
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Resources
User policies
BIONIC is potentially accessible to Â鶹´«Ã½ÊÓƵÍøÕ¾ researchers, as well as external users, on a collaboration basis. Please contact Janos Kriston-Vizi for details.
Collaborations
Sara Mole (LMCB, UK)
Mark Marsh (LMCB, UK)
Dan Cutler (LMCB, UK)
Rob de Bruin (LMCB, UK)
Chris Stefan (LMCB, UK)
Antonella Riccio (LMCB, UK)
Adolfo Saiardi (LMCB, UK)
Alison Lloyd (LMCB, UK)
EM Core Facility (LMCB, UK)
Sarah Tabrizi (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Daniel Hochhauser (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Derek Hausenloy (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Imre Lengyel (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Ariberto Fassati (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Szabadkai Lab (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Masazumi Tada (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Paola Vergani (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Noursadeghi Lab (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Antony N. Antoniou and David Guiliano (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Towers lab, Richard Miles (Â鶹´«Ã½ÊÓƵÍøÕ¾, UK
Paul Gissen (ICH, Â鶹´«Ã½ÊÓƵÍøÕ¾, UK)
Vania Braga (Imperial College London, UK)
Buzz Baum (MRC LMB, UK)
Jason Mercer (Birmingham University, UK))
Hiroyuki Osada (RIKEN CSRS, Japan)Ìý
Hwee Kuan Lee (A-STAR Bioinformatics Institute, Singapore)
Gabor Foldes, Sian Harding (Imperial College, UK)