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Â鶹´«Ã½ÊÓƵÍøÕ¾ Queen Square Institute of Neurology

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MS Research in the MR Physics @ NMR Research Unit

The NMR Research Unit based at the Â鶹´«Ã½ÊÓƵÍøÕ¾ Institute of Neurology has a strong tradition of methodological development for quantitative Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) methods in the central nervous system (CNS).

The Physics team is led by , who is Professor of MR Physics and has been at the Â鶹´«Ã½ÊÓƵÍøÕ¾ QS IoN since 1999, when she joined as Post Doctoral fellow. The MR Physics team currently counts on 6 Post Doctoral researchers and 5 PhD students, and fits within the thriving MR Physics community at Queen Square with collaborations within the Division of Neuroradiology and Neurophysics (Â鶹´«Ã½ÊÓƵÍøÕ¾ QS IoN) and across Faculties, in particular with the Centre of Medical Image Computing (CMIC) (Faculty of Engineering).

The team is particularly focused on developing, implementing and translating methods for studying a number of pathophysiological processes occurring in multiple sclerosis (MS), using standard and advanced imaging techniques applied to brain and spinal cord, as well as optic nerve wherever possible.

Methods include:
- Microstructural imaging using models of water diffusion in tissue;
- Myelin imaging, exploiting the magnetisation transfer phenomenon;
- Tissue loss, through brain atrophy from high resolution imaging;
- Sodium imaging and spectroscopy;
- Functional imaging, both task dependent and resting state;
- Metabolite quantifications.

The Unit currently has a number of Postdoctoral Fellows and also Ph.D. and M.Sc. students working in a truly translational environment where Physicists, Computer Scientists and Clinical Fellows are working in a joint effort to resolve key research questions in MS.

A wide range of imaging techniques for studies on MS are currently utilized in the MR Physics @ NMR Research Unit as shown:

MS imaging techniques
Website page updated 07-02-2020.