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Early Phase Cancer Trials Programme at Â鶹´«Ã½ÊÓƵÍøÕ¾ and Â鶹´«Ã½ÊÓƵÍøÕ¾H

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Sarcoma Trials

A list of our early phase sarcomaÌýtrials which are open to recruitment at University College London Hospitals

To find more information on Â鶹´«Ã½ÊÓƵÍøÕ¾H Early Phase Cancer Clinical Trials, including eligibility criteria, click theÌýhyperlinkedÌýLocal Project Reference (LRP)ÌýID, which will take you to the Â鶹´«Ã½ÊÓƵÍøÕ¾H Find a Â鶹´«Ã½ÊÓƵÍøÕ¾ database.

Additional early phase clinical trials recruiting Sarcoma cohorts may be found in theÌýAdvanced Solid Tumour Trials Portfolio page.

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FaR-RMS

An overarching study for children and adults with Frontline and Relapsed RhabdoMyoSarcoma

Local Project Reference:
Principal Investigator:Dr.ÌýMaria Michelagnoli
Drug Class/ Treatment:

Trial of various Immunotherapy, Targeted Therapy Agents and Radiotherapy.

Patient Population:

Newly Diagnosed and Relapsed Rhabdomyosarcoma (RMS)

AgeÌý>12 months and ≤25 years

Trial Hosted By - Â鶹´«Ã½ÊÓƵÍøÕ¾H Cancer Clinical Trials Unit (CCTU)

SPEARHEAD-1

A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEARâ„¢ T cells in subjects with Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

Local Project Reference:
Principal Investigator:Dr.ÌýSandra Strauss
Drug Class/ Treatment:

ADP-A2M4 SPEARâ„¢ T CellsÌý-ÌýGenetically Modified T-Cells targeting MAGEA4 (Melanoma-Associated Antigen 4)

Patient Population:

Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

Age 16 - 75

Trial Hosted By - Â鶹´«Ã½ÊÓƵÍøÕ¾H Cancer Clinical Trials Unit (CCTU)

LIGHTBEAM-U01 (MK-9999-01a Sub Â鶹´«Ã½ÊÓƵÍøÕ¾)

LIGHTBEAM-U01 Sub study 01A: A Phase 1/2 Sub-study to Evaluate theÌý Safety and Efficacy of Zilovertamab Vedotin in Paediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumours

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Local Project Reference:162764
Pincipal Investigator:Dr Rachel Windsor
Drug Class/ Treatment:

Zilovertamab Vedotin -ÌýAntibody-Drug Conjugate

Patient Population:

Paediatric Patients (1 - <18 Years):

  • B-ALL
  • DLBCL/Burkitt Lymphoma
  • Neuroblastoma

Paediatric and Young Adult Patients (Birth - 25 Years):

  • Ewing Sarcoma
Trial Hosted By - Â鶹´«Ã½ÊÓƵÍøÕ¾H Cancer Clinical Trials Unit (CCTU)

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