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Centre for Cardiometabolic and Vascular Science
翱耻谤听overall goal is to听understand the听regulation of lipid metabolism听at the level of gene expression, mainly mediated by the Liver X Receptor (LXR). We听focus听on how metabolic and immune pathways impact the progression of听metabolic, cardiovascular and autoimmune disease progression.听We have generated unique molecular biology tools, knock-in and knock-out animal and cellular models that have increased our understanding of how the activity of these receptors is modulated in contexts where lipid homeostasis is disturbed.听We have expertise in the听functional analysis of global high-throughput datasets and听have applied our expertise in transcriptomic, metabolomic and lipidomic analyses to investigate听the crosstalk between lipid metabolism and immunity in animal models (diet-induced atherosclerosis and non-alcoholic fatty liver disease) and in human immune cells. Currently, through听multidisciplinary collaborative efforts, we aim to build novel computational tools to better understand sex- and disease-specific differences in immune cell lipid metabolism and generate signatures towards better patient stratification for future pharmacological or nutritional interventions.
Professor Zachary's research is听supported by funding from the British Heart Foundation,听his work investigates how the essential angiogenic factor, Vascular Endothelial Growth Factor (VEGF), signals endothelial cells form new blood vessels, with major interests in听signalling听in endothelial cell migration, and the role of Neuropilin-1.听These questions are addressed using diverse techniques in cell and molecular biology,听in-vivo zebrafish and genetically altered mutant mice models.
Part of the听translational research is led听by Professor John Martin on听the use of stem cells for treating heart disease.听The Centre received a听grant听by the UK Stem Cell Foundation to perform a clinical trial of autologous stem cells and repair of the heart immediately after a heart attack.听
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