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Animated film on CAR T-cell therapy launched for GCSE students

11 April 2019

The Â鶹´«Ã½ÊÓƵÍøÕ¾H Biomedical Research Centre (BRC) has today launched an animated film for GCSE and A level students on CAR T-cell therapy – a revolutionary approach to the treatment of cancer in development at Â鶹´«Ã½ÊÓƵÍøÕ¾ and Â鶹´«Ã½ÊÓƵÍøÕ¾H.

Biohackers - CAR T-cell animated film for GCSE students

The film, which is hosted on the website of TED-Ed, the youth and education initiative of TED Talks, has been developed with science teachers to be in line with the school science curriculum. Accompanied by student worksheets and teachers’ guide, the film is designed to be used in the classroom.Ìý

The BRC, which supports a large portfolio of CAR T studies across Â鶹´«Ã½ÊÓƵÍøÕ¾ and Â鶹´«Ã½ÊÓƵÍøÕ¾H, developed the film, written by science presenter Greg Foot, in collaboration with Â鶹´«Ã½ÊÓƵÍøÕ¾ scientists and Â鶹´«Ã½ÊÓƵÍøÕ¾H clinicians involved in CAR T research.

Dr Martin Pule, who leads the Â鶹´«Ã½ÊÓƵÍøÕ¾ CAR T-cell programme and who advised on the film, said: “I’m delighted to see the film come to fruition and with the way it turned out. The film really gets across how exciting this emerging treatment is, and explains it in a way which students will engage with.â€

CAR T-cell therapy is a form of personalised treatment for patients who do not respond to standard anti-cancer treatments like chemotherapy, and has been shown in trials to cure some patients with cancer, even those with advanced cancers.

It has so far shown most promise for haematological (blood) cancers, and Â鶹´«Ã½ÊÓƵÍøÕ¾H consultant haematologist Professor Emma Morris has said the therapy represents ‘a real step change in how we treat cancers.’

T-cells are part of our immune system which normally kill infected cells. In CAR T therapy, they are taken from a person’s blood sample, grown in the laboratory and ‘re-programmed’ to recognise and kill cancer cells just as they would naturally attack an infection. This re-programming is achieved by introducing a gene for an artificial protein called a chimeric antigen receptor, or CAR for short.

The treatment is part of the NHS’s long term plan to upgrade cancer services.

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